Celiac gene test from raw data
Review celiac-related HLA context from your raw DNA file.
GenoSight can re-analyze a compatible 23andMe, AncestryDNA, or MyHeritage raw DNA file for supported HLA-DQ tag SNPs, then explain what they can and cannot say in an educational Gut Health report.
Gut Health report
160 credits; free signup grant is 250 credits.
What raw DNA can and cannot show
Celiac genetics is useful mainly as context for a clinical conversation. A consumer raw DNA file is not a clinical HLA typing result, and a positive tag SNP is not a diagnosis.
HLA-DQ context
DQ2 and DQ8 are rule-out context
Clinical celiac workups may use HLA-DQ2 and HLA-DQ8 testing to help rule out celiac disease. Consumer raw files usually provide tag SNPs, not definitive HLA typing.
Tag SNPs
Raw DNA coverage varies
GenoSight can look for supported markers such as rs2187668 and rs7454108 when present, then explain what they can and cannot say.
Clinical boundary
Symptoms and labs lead
Celiac diagnosis depends on medical history, blood tests, and sometimes biopsy. A raw DNA report is only educational background.
Report paths
Start with Gut Health or Foods & Drinks.
Both starter reports fit inside the no-card credit grant. The broader Nutrition report is there if your question extends into nutrient and diet-related genetics.
Gut Health report
160 creditsBest first stop for celiac tag SNPs, lactose context, histamine clearance, gut barrier, and digestion-related genetics.
ContinueFoods & Drinks report
160 creditsUseful when your gluten question sits beside lactose, histamine, caffeine, alcohol, taste, or other food-response questions.
ContinueNutrition report
350 creditsA deeper paid-intent report for broader food, nutrient, and diet-related genetics beyond celiac context alone.
ContinueWhat GenoSight can explain
Check supported celiac-related HLA tag SNPs when they are present in your raw DNA file
Explain why negative DQ2/DQ8 context can be useful for rule-out discussions
Separate celiac genetics from gluten sensitivity, wheat allergy, IBS, and FODMAP questions
Generate a Gut Health report that fits inside the no-card signup credit grant
What it should not do
Diagnose celiac disease, non-celiac gluten sensitivity, wheat allergy, IBS, or autoimmune disease
Replace tTG-IgA, total IgA, EMA-IgA, endoscopy, biopsy, or clinician-ordered HLA typing
Tell you to start or stop a gluten-free diet
Analyze PDF reports, screenshots, FASTQ, BAM, or whole-genome VCF files
Celiac gene test questions
Common questions before checking HLA tag SNPs.
Can I use 23andMe or AncestryDNA raw data for a celiac gene test?
You can use a compatible 23andMe, AncestryDNA, or MyHeritage raw genotype file to review supported celiac-related tag SNPs. This is educational context only, not clinical HLA typing or a diagnosis.
Can HLA-DQ2 or HLA-DQ8 diagnose celiac disease?
No. HLA-DQ2 and HLA-DQ8 are common in the general population, so a positive genetic result does not diagnose celiac disease. Clinical sources describe genetic testing as more useful for helping rule out celiac disease in selected circumstances.
Should I stop eating gluten before testing?
Do not change your diet because of a consumer raw DNA result. NIDDK notes that starting a gluten-free diet before diagnostic testing can affect test results, so symptoms or family-history concerns belong with a clinician.
Can I try this before paying?
Yes. New accounts receive 250 free credits with no card required. The Gut Health and Foods & Drinks reports currently cost 160 credits each, so the free grant can cover a first celiac-context report preview.
No-card starter path
Review celiac-related context with the free credit grant.
Upload a compatible raw DNA file, generate a Gut Health report, and bring any symptom or family-history concern to a clinician.