MTHFR and COMT report
Turn MTHFR and COMT raw data into a careful report.
GenoSight can use a compatible 23andMe, AncestryDNA, or MyHeritage raw DNA file to build an educational Detox and Methylation report around selected MTHFR, COMT, folate, and B-vitamin context. It does not measure methylation levels or prescribe supplements.
Good fit when
You want a report, not a SNP table.
You already have a compatible raw DNA file
You want MTHFR and COMT explained together
You want caveats before making health decisions
You understand this is educational, not clinical testing
Report scope
MTHFR and COMT belong in context.
A useful report should show the marker, explain the caveat, and slow down over-confident supplement conclusions.
MTHFR C677T and A1298C
Reviews the common MTHFR markers people usually search for, when those rsIDs are present and called in the raw file.
Learn moreCOMT rs4680 Val158Met
Frames COMT in context around catecholamine breakdown, methylation-related biology, and supplement caution.
Learn moreFull Detox and Methylation report
Connects single-marker findings to folate, B-vitamin, phase I and phase II detox context, MTR, MTRR, and report-level uncertainty.
Learn moreBefore paying
Confirm the basics first.
Check marker coverage first
The local checker can show whether selected MTHFR, COMT, MTR, and MTRR rsIDs appear in your file before upload.
Run local checkerUse the right raw file
GenoSight needs the extracted raw genotype text, CSV, or TSV file from 23andMe, AncestryDNA, or MyHeritage, not a ZIP archive, PDF report, or screenshot.
Check file typeStart with free credits
The first Detox and Methylation report fits inside the no-card signup grant when your file is compatible.
Start freePricing path
Try the report before paying.
New accounts receive 250 credits with no card required. Choose monthly when you already know you want more reports, PDFs, regeneration, and findings-grounded chat.
Free trial
$0
250 signup credits
Run the first Detox and Methylation report with your own compatible raw file before paying.
Start freeMonthly
$11.99
1,500 credits per month
Best when MTHFR and COMT are the first report and you want PDFs, more reports, and follow-up chat.
Choose monthlyYearly
$99.99
18,000 credits per year
Best when you expect to work through broader raw DNA report areas after the methylation report.
Choose yearlyA GenoSight report can
Show selected MTHFR and COMT variants when your raw file contains them
Explain why one marker should not become a diagnosis or supplement protocol
Add source notes, caveats, PDFs, and findings-grounded chat on paid plans
Help you prepare better questions for a clinician or genetic counselor
A GenoSight report cannot
Measure DNA methylation levels, epigenetic age, homocysteine, folate, or B12
Diagnose an MTHFR-related condition or methylation disorder
Tell you to start, stop, or dose methylfolate, B12, or other supplements
Replace clinical testing when symptoms, pregnancy planning, or medications are involved
Keep gene results proportional.
MTHFR and COMT searches often lead to confident advice from single markers. GenoSight keeps the output educational and makes space for labs, symptoms, medications, pregnancy status, and clinician guidance.
Privacy and processing boundary
GenoSight uploads the raw file to your account so report generation, PDFs, and paid-plan chat can work across sessions. The raw genotype file is processed by the analysis pipeline; the language model receives structured findings and your profile context, not the raw genotype text file.
Source notes
Public references used for this guide.
MedlinePlus Genetics: MTHFR
NIH consumer genetics reference for MTHFR and common folate-pathway variant context.
NCBI Gene: COMT
Reference entry for catechol-O-methyltransferase and O-methylation of catecholamine transmitters.
Raw DNA provider download guide
GenoSight guide with official-source-backed raw data download steps for supported providers.
FAQ
MTHFR and COMT report questions.
Can GenoSight make an MTHFR and COMT report from raw DNA?
Yes, if your file is a compatible raw genotype export from a supported provider. GenoSight can run an educational Detox and Methylation report that frames selected MTHFR and COMT variants with caveats and source context.
What DNA test should I buy for MTHFR and COMT?
For a consumer raw-data workflow, the key requirement is raw data download capability and coverage of common markers such as MTHFR rs1801133, MTHFR rs1801131, and COMT rs4680. GenoSight can read compatible 23andMe, AncestryDNA, or MyHeritage raw files, but provider chip coverage and file formats can change, so check marker coverage before treating any kit as complete.
Is this a methylation test?
No. A raw DNA genotype file is not an epigenetic methylation assay. GenoSight reviews inherited variants; it does not measure methylation levels, epigenetic age, homocysteine, folate, or B12.
What if my file is missing an MTHFR or COMT marker?
Missing markers can reflect chip coverage, no-calls, or provider differences. A missing marker in a consumer raw file is not a clinical result by itself.
Can this report recommend methylfolate or supplements?
No. GenoSight keeps the output educational. Supplement decisions depend on labs, diet, symptoms, medications, pregnancy status, and clinician guidance.