MTHFR raw DNA report
Check MTHFR from the raw DNA file you already have.
If you are looking for an MTHFR test, GenoSight can re-analyze an existing 23andMe, AncestryDNA, or MyHeritage raw DNA file and show C677T, A1298C, and related methylation context in a readable educational report.
Not a new lab test
Re-analysis of compatible consumer raw data.
New accounts include 250 free credits, so you can test the report style before choosing a paid plan.
What the MTHFR report covers
MTHFR is useful only when it is kept in proportion. GenoSight shows the variant calls, then explains what is known, what is overstated online, and what belongs with a clinician.
C677T and A1298C
GenoSight looks for the two common MTHFR variants people usually mean: C677T (rs1801133) and A1298C (rs1801131), when present in the raw file.
Methylation context
The report does not stop at one SNP. It also considers related methylation and B-vitamin context, including MTRR, COMT, folate, B12, and your stated goals.
No diagnosis
Consumer raw DNA data is not clinical confirmation. GenoSight is for education and clinician conversations, not diagnosis or prescribing decisions.
Why context matters
The genotype is only the first clue.
MTHFR variants are common. A readable report should not turn a common polymorphism into a diagnosis. It should help you ask better questions about folate, B12, homocysteine, pregnancy planning, supplement forms, and whether follow-up labs make sense for your situation.
- Shows whether the raw file contains rs1801133 and rs1801131
- Explains C677T and A1298C without internet hype
- Keeps raw-file re-analysis separate from clinical testing
- Links to broader Nutrition and Detox & Methylation reports
Medical boundary
GenoSight is educational. It does not replace clinical MTHFR testing, genetic counseling, homocysteine labs, prenatal guidance, or medication advice.
NIH ODS notes that people with the MTHFR 677C>T polymorphism have reduced ability to convert folate to 5-MTHF, but also states that this information should not take the place of medical advice. GenoSight keeps that boundary visible throughout the report.
MTHFR report questions
Is this a clinical MTHFR test?
No. GenoSight is not a laboratory test and does not diagnose MTHFR-related conditions. It re-analyzes compatible consumer raw DNA files for educational reporting.
Can 23andMe, AncestryDNA, or MyHeritage show MTHFR?
These raw genotype files commonly include the MTHFR C677T and A1298C markers, but coverage can vary by chip version. GenoSight checks your uploaded file before analysis.
Does an MTHFR variant mean I need methylfolate?
Not automatically. NIH ODS notes that people with the 677C>T polymorphism have reduced ability to convert folate to 5-MTHF, but supplement decisions depend on labs, pregnancy status, diet, symptoms, and clinician guidance.
Can I try it before paying?
Yes. New accounts get 250 free credits with no card required, enough to try the report format before choosing a paid plan.
Free credits, no card