23andMe MTHFR raw data
Does 23andMe test MTHFR?
Sometimes the answer means a named 23andMe report. Sometimes it means whether your raw data contains rs1801133 or rs1801131. GenoSight helps with the second path: re-analyzing a compatible raw genotype file into a readable educational MTHFR report.
Two questions get mixed together
Report availability and raw-marker coverage are separate.
- Named 23andMe report availability can change
- Raw data may include rs1801133 and rs1801131
- GenoSight checks compatible raw genotype files
- Educational only, not clinical confirmation
The careful answer
MTHFR has enough online hype that the wording matters. Start by separating a consumer report, raw data lookup, and clinical testing into three different buckets.
If you mean a 23andMe report
23andMe product menus and regional availability can change. 23andMe has discussed MTHFR-related homocysteine reporting, but a named report is not the same thing as a full methylation interpretation.
If you mean raw data
23andMe raw data can be searched by gene, rsID, or position. The two common MTHFR markers people usually ask about are C677T rs1801133 and A1298C rs1801131, but coverage can vary.
If you mean medical testing
Consumer raw DNA is informational. A clinical question belongs with a qualified clinician, appropriate labs, and clinical-grade testing when needed.
Source boundaries
23andMe describes raw data as informational, and its raw-data help center explains searching by gene, marker, or position. GenoSight keeps the same boundary: raw DNA is useful context, not a diagnosis or treatment plan.
What to do with a 23andMe raw file
Check coverage first
Use the local MTHFR/COMT checker to see whether rs1801133, rs1801131, and rs4680 appear in your file.
ContinueRead the marker page
Use the 23andMe rs1801133 page to keep C677T marker lookup, coverage, and interpretation boundaries separate.
ContinueRun the report
Use the Detox & Methylation report when you want MTHFR framed alongside COMT, folate, B vitamins, goals, and caveats.
Continue23andMe and MTHFR questions
Does 23andMe include MTHFR?
It depends what you mean. Some 23andMe products may include MTHFR-related reporting, and raw data can often be searched for common MTHFR markers such as rs1801133 and rs1801131. Coverage and report availability can vary.
Which MTHFR markers should I search for in 23andMe raw data?
The two common markers are C677T rs1801133 and A1298C rs1801131. A raw genotype string is only the starting point, especially because strand orientation and missing coverage can confuse direct comparisons.
Can GenoSight read my 23andMe raw data for MTHFR?
Yes. GenoSight can analyze a compatible 23andMe raw genotype file and frame MTHFR alongside COMT, folate and B-vitamin context, and report caveats. It is educational only, not diagnosis or prescribing advice.
Can I check the markers before uploading a file?
Yes. GenoSight has a browser-only MTHFR and COMT marker checker that runs locally and shows marker presence plus raw genotype strings without interpreting them.