Local MTHFR and COMT marker checker
Check MTHFR and COMT markers in your raw DNA file.
Drop in a 23andMe, AncestryDNA, or MyHeritage raw genotype file to see whether it contains selected MTHFR, COMT, MTR, and MTRR rsIDs. The scan runs locally in your browser and shows raw file values only.
Want to see the output first? Use the synthetic marker example.
This checker reports marker presence and the raw genotype string only. It does not classify alleles, diagnose conditions, recommend supplements, or send your genotype data to GenoSight.
The first question is coverage, not interpretation.
People often search for MTHFR or COMT before knowing whether their raw file even contains the marker. This page answers that smaller question without making health claims.
MTHFR C677T
Looks for rs1801133, the common MTHFR marker many people mean when they ask about C677T.
MTHFR A1298C
Looks for rs1801131, often discussed together with C677T in methylation searches.
COMT Val158Met
Looks for rs4680, the common COMT marker discussed around catecholamine breakdown and methylation context.
Why this page avoids allele labels
MTHFR and COMT results are easy to overinterpret. A raw genotype string can be strand-dependent, chip-dependent, and incomplete. GenoSight keeps the free checker narrow, then handles context in the full educational report.
See methylation report contextGuardrails
Useful without pretending to be clinical.
- Shows marker presence and raw genotype strings only
- Does not label alleles as good, bad, fast, or slow
- Does not recommend methylfolate, supplements, or medication changes
- Does not upload the raw DNA file to GenoSight
MTHFR and COMT raw data questions
Can I check MTHFR and COMT from my 23andMe raw data?
Often, yes. This checker looks for common rsIDs such as MTHFR rs1801133, MTHFR rs1801131, and COMT rs4680 in a raw genotype file. Coverage can vary by provider and chip version.
Does the checker interpret my genotype?
No. It only shows whether selected markers are present and the raw genotype string reported in the file. Interpretation requires broader context and should not be reduced to a single SNP.
Why does the genotype sometimes look different from SNPedia?
Consumer providers and public databases can report variants on different DNA strands. This checker avoids translating strand orientation on the free page so it does not overstate a result.
What should I run after finding MTHFR or COMT markers?
For GenoSight, the most direct first report is Detox & Methylation, which fits inside the 250-credit no-card signup grant. Reports remain educational and are not clinical diagnosis.
250 free credits, no card