MTHFR A1298C raw DNA marker
MTHFR A1298C rs1801131 in raw DNA data.
If you are searching your raw DNA file for MTHFR, rs1801131 is the A1298C marker often discussed next to C677T. GenoSight can check marker coverage locally, then place the result inside a cautious educational methylation report.
Marker-first workflow
Check coverage before you interpret anything.
- Browser-only local marker check
- Raw genotype string only
- No methylfolate recommendation on the free page
- Full report adds C677T, COMT, and B-vitamin context
A1298C usually needs C677T context.
A1298C is frequently discussed with C677T, but it should not be interpreted as a standalone methylation diagnosis. A useful report keeps the raw call, missing coverage, strand caveats, and health context separate.
What rs1801131 is
rs1801131 is the common MTHFR A1298C marker people often search for after checking C677T in a consumer raw genotype file.
What it is not
A raw rs1801131 genotype is not a methylation-level test, diagnosis, or supplement instruction. It is one inherited marker that needs context.
How GenoSight handles it
GenoSight checks whether the marker is present, then frames A1298C alongside C677T, COMT, folate context, goals, symptoms, and clinician boundaries.
Evidence boundary
MedlinePlus describes C677T and 1298A>C as the two most common and frequently studied MTHFR polymorphisms. That does not make a raw consumer genotype a clinical result. Clinically meaningful decisions belong with appropriate labs and a qualified clinician.
MTHFR A1298C rs1801131 questions
Can I find MTHFR A1298C rs1801131 in my 23andMe raw data?
Often, yes, but coverage varies by provider and chip version. Use the browser-only MTHFR and COMT checker to see whether rs1801131 is present in your specific raw file.
Why might my file show T/G or G/G instead of A/C or C/C?
Consumer raw files and public databases can represent variants on different DNA strands. That is why GenoSight separates marker detection from interpretation and avoids overclaiming from raw letters alone.
Does MTHFR A1298C mean I need methylfolate?
Not automatically. Supplement decisions depend on labs, diet, pregnancy status, symptoms, medications, and clinician guidance. GenoSight reports are educational, not prescribing advice.
Which GenoSight report should I start with?
For MTHFR A1298C questions, Detox & Methylation is the most direct first report. It currently fits inside the 250-credit no-card signup grant.