COMT gene test
Check COMT from the raw DNA file you already have.
GenoSight can re-analyze a compatible 23andMe, AncestryDNA, or MyHeritage raw DNA file for COMT rs4680 Val158Met, then explain it in context across methylation, dopamine-related biology, stress sensitivity, and supplement discussions without turning a single variant into a diagnosis.
Free grant covers first-pass reports
250 signup credits, no card required.
What the COMT report explains
COMT is useful only when it is kept proportional. GenoSight shows the variant call when your file contains it, then explains what is known, what is uncertain, and what needs professional context.
COMT rs4680 / Val158Met
GenoSight checks supported COMT markers such as rs4680 when they are present in your raw DNA file, then explains the result without treating it as destiny.
Methylation and catecholamines
COMT is part of methylation-related biology and catecholamine breakdown. Reports connect it to MTHFR, B vitamins, stress context, and stated goals.
Anti-hype framing
The report avoids "warrior/worrier" identity claims and does not tell you to start or stop supplements from a single genotype.
Beyond the "slow COMT" label
Internet shorthand often turns COMT into a personality label or supplement rule. GenoSight treats it as one biochemical clue inside a larger profile: methylation, caffeine and stimulant response, stress, sleep, current supplements, and personal goals.
- Shows whether supported COMT markers are present in your file
- Connects COMT with MTHFR and methylation context when relevant
- Separates enzyme-activity discussion from diagnosis
- Avoids single-SNP supplement rules and "warrior/worrier" certainty
Use your existing file
No new lab test required. Upload a compatible raw genotype file from 23andMe, AncestryDNA, or MyHeritage.
Medical boundary
GenoSight is educational. It does not diagnose mood disorders, methylation problems, medication response, or supplement needs.
Context-first interpretation
The same COMT call can be framed differently depending on sleep, caffeine, stress, symptoms, medications, and supplement stack.
Provider-specific COMT answers
Raw-data coverage depends on the provider and chip version. Use the provider guide when you want the exact download and marker lookup path before running a report.
Evidence boundary
COMT is a real protein-coding gene with a well-studied Val158Met variant, but many everyday claims around it are overconfident. GenoSight links claims to source material and keeps the output modest.
Free first, monthly if useful
Ready to put COMT into report context?
FAQ
Can GenoSight check my COMT gene from 23andMe or AncestryDNA?
Yes, when the compatible raw DNA file includes supported COMT markers such as rs4680. Coverage can vary by provider and chip version, so GenoSight checks the uploaded file before reporting.
What does slow COMT mean?
"Slow COMT" usually refers to the COMT Val158Met rs4680 Met-associated enzyme-activity pattern. It is a biochemical tendency, not a diagnosis or personality type.
Does COMT tell me which supplements to take?
No. COMT can be one clue in a broader methylation and catecholamine picture, but supplement decisions depend on symptoms, labs, medications, diet, pregnancy status, and clinician guidance.
Can I try the COMT report before paying?
Yes. New accounts receive 250 free credits with no card required. The Detox & Methylation, Mental Wellbeing, and Personality reports each fit within the free signup grant.