Detox and Methylation report
Run the Detox and Methylation report from your raw DNA file.
GenoSight can use a compatible 23andMe, AncestryDNA, or MyHeritage raw DNA file to build an educational report across methylation, phase I and phase II detoxification, and selected substance-response context. It keeps raw genotype findings separate from clinical testing, labs, symptoms, and supplement decisions.
Fits the no-card starter path
200 credits from a 250-credit signup grant.
Report scope
The report connects methylation and detox pathways without overpromising.
The goal is a readable, cautious report that helps you understand selected raw-file markers in context, not a protocol for treating symptoms or changing medications.
Methylation cycle
Frames selected MTHFR, MTR, MTRR, AHCY, and COMT findings when those markers are present, while separating genotype from lab markers like homocysteine, folate, and B12.
Phase I detoxification
Reviews selected CYP-family markers that can be relevant to caffeine, smoke exposure, cooked-meat compounds, hormones, and medication-response conversations.
Phase II detoxification
Adds context around GST, NAT, UGT, SULT, and related conjugation pathways without turning raw DNA into a detox cleanse or supplement protocol.
Exposure and substance context
Keeps findings practical by discussing environmental loading, cruciferous-vegetable style lifestyle context, and clinician follow-up boundaries.
Raw file workflow
Start with the file and marker coverage before paying.
A missing marker can mean provider chip coverage, a no-call, or a file-format issue. GenoSight keeps that uncertainty visible so the report does not pretend the raw file is a clinical panel.
Check your raw file
Use the extracted raw genotype text, CSV, or TSV file from 23andMe, AncestryDNA, or MyHeritage. GenoSight does not analyze ZIP archives, PDF reports, or screenshots.
Check file typePreview methylation markers
The browser-only checker can show whether selected MTHFR, COMT, MTR, and MTRR rsIDs appear in your file before upload.
Run local checkerRun the focused report
The Detox and Methylation report currently costs 200 credits, so it fits inside the 250-credit no-card signup grant when your file is compatible.
Start freeWhat this report can do
Show selected methylation and detoxification variants when your raw file contains them
Explain why MTHFR, COMT, CYP, GST, and NAT markers need source notes and caveats
Separate raw genotype findings from lab values, symptoms, medication context, and clinical decisions
Create a readable PDF-style report and unlock findings-grounded chat on paid plans
What this report cannot do
Measure DNA methylation levels, epigenetic age, homocysteine, folate, B12, or toxin burden
Diagnose methylation disorders, detoxification impairment, chronic disease, or medication safety
Tell you to start, stop, or dose methylfolate, B12, NAC, glutathione, or other supplements
Replace clinical pharmacogenomic testing, medical care, pregnancy guidance, or genetic counseling
Pricing
Try the report before a paid plan.
The free signup grant is sized for this report. Paid plans are for people who want more reports, PDFs, regenerations, and findings-grounded follow-up chat.
Free trial
$0
250 signup credits
Best first step when you want the Detox and Methylation report from your own compatible file before paying.
Start freeMonthly
$11.99
1,500 credits per month
Best when this report raises follow-up questions and you want PDFs, additional reports, and findings-grounded chat.
Choose monthlyYearly
$99.99
18,000 credits per year
Best when Detox and Methylation is the first step in a broader raw DNA report library review.
Choose yearlyRelated pages
Choose the narrower page if your question is more specific.
Searchers arrive with different language. These paths all route back to the same careful raw-DNA workflow and clinical boundary.
Genetic detox test
Use this page if your search started with detox genes, Phase I or Phase II detoxification, CYP, GST, or NAT.
Open pageMTHFR and COMT report
Use this page if your main question is specifically MTHFR C677T, MTHFR A1298C, or COMT rs4680.
Open pageMethylation analysis from raw DNA
Choose a provider-specific path for 23andMe, AncestryDNA, or MyHeritage raw DNA methylation context.
Open pageSource notes
The report keeps source context visible.
MedlinePlus Genetics: MTHFR
NIH consumer genetics reference for MTHFR, folate processing, homocysteine context, and common polymorphism caveats.
View sourceNCBI Gene: COMT
Reference entry describing catechol-O-methyltransferase and methyl-group transfer in catecholamine metabolism.
View sourceLinus Pauling Institute: Folate
Micronutrient reference for folate-dependent one-carbon metabolism and homocysteine remethylation context.
View sourceDetox and Methylation report questions
Can GenoSight run a Detox and Methylation report from raw DNA?
Yes, if the file is a compatible consumer raw genotype export from a supported provider. GenoSight can generate an educational Detox and Methylation report that frames selected MTHFR, COMT, CYP, GST, NAT, and related markers with caveats and source context.
Does this report prove I have a methylation or detox problem?
No. A consumer raw DNA file shows inherited genotype calls, not methylation levels, toxin burden, homocysteine, folate, B12, symptoms, or medication safety. The report is educational and should not be used as diagnosis.
Can this report tell me what supplements to take?
No. GenoSight does not prescribe methylfolate, B12, glutathione, NAC, detox cleanses, or supplement dosing. Those decisions depend on labs, diet, symptoms, medications, pregnancy status, and clinician guidance.
Will the free credits cover this report?
The Detox and Methylation report currently costs 200 credits. New accounts receive 250 signup credits with no card required, so the first report fits inside the free grant when the raw file is compatible.
250 free credits, no card