Methylation analysis from raw DNA
Run methylation analysis from the raw DNA file you already have.
Upload a compatible 23andMe, AncestryDNA, or MyHeritage raw DNA file and start with an educational Detox and Methylation report. GenoSight explains selected MTHFR, COMT, folate, and B-vitamin context without claiming to measure methylation levels.
Educational boundaries
Raw DNA is not a methylation lab.
No methylation-level measurement
No diagnosis or treatment plan
No supplement dosing from genotype alone
Provider coverage can vary by chip version
Provider paths
Start with the company that generated your raw file.
23andMe raw data
Use this path if your file came from a 23andMe raw genotype download and you want MTHFR, COMT, folate, and B-vitamin context.
Open provider guideAncestryDNA raw data
Use this path if you extracted the text file from an AncestryDNA raw data ZIP export and want careful methylation-related reporting.
Open provider guideMyHeritage raw DNA data
Use this path if your file came from a MyHeritage DNA kit and you want educational MTHFR and COMT context.
Open provider guideMake the report useful without over-reading the file.
Raw genotype files are useful for selected inherited-variant lookup, but they are not live biochemical measurements. GenoSight is designed to keep that distinction visible.
What raw DNA can show
A compatible raw genotype file can show selected inherited variants such as MTHFR C677T, MTHFR A1298C, and COMT Val158Met when those markers are present and called.
What GenoSight adds
GenoSight turns selected marker findings into a readable educational Detox and Methylation report with citations, caveats, PDFs, and findings-grounded chat on paid plans.
What raw DNA cannot show
A consumer raw DNA file does not measure DNA methylation levels, homocysteine, folate, B12, symptoms, medication context, or epigenetic age.
Workflow
Three ways to reduce uncertainty before you pay.
Check file type first
Use the extracted raw genotype text, CSV, or TSV file from a supported provider. GenoSight does not analyze ZIP archives, PDF reports, screenshots, FASTQ, BAM, or whole-genome VCF files.
Check filePreview marker coverage
Use the browser-only local checker to see whether selected MTHFR, COMT, MTR, or MTRR rsIDs appear before uploading.
Check markersRun the report
New accounts receive 250 credits with no card required, enough for the first Detox and Methylation report when the file is compatible.
Detox and Methylation reportPricing path
Try the methylation report before paying.
The free signup grant is built for trying a real report first. Choose monthly only when the first result makes you want more credits, PDFs, regeneration, and findings-grounded chat.
Free trial
$0
250 signup credits
Best first step when you want to test the Detox and Methylation report with your own raw file before paying.
Start freeMonthly
$11.99
1,500 credits per month
Use monthly when methylation is the first report and you want PDFs, regeneration, more report domains, and chat.
Choose monthlyYearly
$99.99
18,000 credits per year
Use yearly when you expect to work through the broader raw DNA report library after methylation.
Choose yearlySource notes
Public references used for this guide.
FAQ
Methylation analysis from raw DNA questions.
Can I run methylation analysis from raw DNA data?
Yes, if the file is a compatible consumer raw genotype export from a supported provider. GenoSight can generate an educational Detox and Methylation report that frames selected methylation-related variants such as MTHFR and COMT with caveats and source context.
Is this a DNA methylation test?
No. A raw genotype file is not an epigenetic methylation assay. GenoSight reviews inherited variants; it does not measure methylation levels, epigenetic age, homocysteine, folate, or B12.
Which raw DNA providers work best?
GenoSight is built around compatible 23andMe, AncestryDNA, and MyHeritage raw genotype files. The exact marker coverage depends on the provider file, chip version, and no-call results.
Can this tell me which methylated supplements to take?
No. GenoSight keeps the output educational. Supplement decisions depend on labs, diet, symptoms, medications, pregnancy status, and clinician guidance, not raw DNA alone.