Promethease alternative: GenoSight

1. GenoSight: readable reports and follow-up

Best for: People with a supported consumer raw DNA file who want an educational topic report, citations, a PDF and follow-up questions.

GenoSight starts from the file you already have. Choose a report topic, review the explanation and its caveats, then decide whether more reports or paid-plan chat are useful. The sample report shows the structure before you upload sensitive data.

The no-card trial includes 250 signup credits. Report costs vary from 100 to 350 credits, so the trial can cover one 200-credit report or two 100-credit reports, but it does not cover the 350-credit Nutrition report by itself. Paid-plan findings chat costs one credit per message. Check the current plans and report costs before choosing.

Honest limitation: GenoSight is hosted and credit-based. It is unsuitable when all processing must stay in your browser or when you need interpretation of whole-genome FASTQ, BAM or VCF files. Its educational output is not a diagnostic test.

2. Genetic Genie: free research tools

Best for: People who want free variant exploration or focused methylation and detox panels and are comfortable researching individual findings.

Genetic Genie describes its tools as free and anonymous. Its panels and GenVue have different compatibility lists, so check the particular tool rather than assuming every accepted format works everywhere. Its homepage says GenVue uses ClinVar and other databases for variant research.

Honest limitation: These are research tools. Finding a variant in a database is not enough to establish a diagnosis or justify a treatment change. GenoSight is a different reading workflow, not proof of superior medical interpretation.

3. Promethease: keep it for literature lookup

Best for: Readers who want to explore genotype-level annotations and follow the literature linked through SNPedia.

Promethease describes its product as a literature retrieval system that connects a genotype file to SNPedia-cited findings. Keeping that report can be useful even if you also use a clearer topic summary elsewhere; switching does not require discarding your original research.

Checked October 12, 2026: most reports cost USD $25, and each additional file in the same report adds USD $4. A typical two-file report therefore totals USD $29 before any checkout adjustments. Confirm the amount for your files at checkout; the homepage notes longer runtime for much larger files.

Honest limitation: Literature lookup leaves the reader responsible for deciding which annotations answer the question and whether the underlying evidence applies. Promethease is the stronger fit when that exploration is the work you want to do.

Switch using your original file

1. Keep your original provider download and any report you want to retain. A Promethease report is not a replacement for a raw genotype file.
2. Confirm the receiving tool accepts your provider and file type. GenoSight supports compatible 23andMe, AncestryDNA and MyHeritage raw files, not PDFs or screenshots. Use the download and upload guide.
3. Review the service's processing and deletion terms before sending genetic data. GenoSight is hosted; its privacy policy describes the data boundary. Do not assume every alternative is local-only.
4. Try one report addressing your actual question. Compare its sources, missing-data caveats and explanation with your existing report before spending more.

The FDA explains that consumer genetic tests differ in the variants they examine and in the evidence supporting their claims. Discuss concerning results with a qualified healthcare professional before changing medical care. Re-analysis software does not measure DNA positions absent from the original file.

For the broader kit-versus-upload decision, see our comparison of GenoSight, Promethease, SelfDecode and Nebula. This page focuses on switching from Promethease.