Promethease alternative
Raw DNA reports people can actually read.
GenoSight turns your existing 23andMe, AncestryDNA, or MyHeritage raw DNA file into educational reports with citations, caveats, and context. It is built for people who want more synthesis than a giant SNP table, without pretending consumer data is a medical diagnosis.
What GenoSight reads
Consumer raw DNA files, not PDFs or screenshots.
- Reads existing 23andMe, AncestryDNA, and MyHeritage raw files
- Prioritizes findings into readable educational reports
- Separates lifestyle, pharmacogenomics, ClinVar-style flags, and carrier-status context
- Shows caveats instead of treating consumer chip data as diagnosis
Less raw lookup, more synthesis
Promethease-style reports are useful when you want every matched variant. GenoSight is for people who want the important findings grouped, caveated, and written in plain language.
Ask follow-up questions
Paid GenoSight plans include chat grounded in your generated findings, so you can ask what a result means instead of hunting through a long static report.
Educational by design
Consumer chip data can be useful for learning and triage, but it is not clinical confirmation. GenoSight keeps that boundary visible throughout the report.
From table to report
When SNP rows are not enough, the job changes.
Many people start with raw variant lookup, then realize they need help sorting signal from noise. GenoSight is built around report topics, caveats, and next-question context rather than a single giant table.
MTHFR is not the whole story
Methylation-related pages route readers toward broader Detox & Methylation context rather than treating one MTHFR result as a complete answer.
COMT needs boundaries
COMT variants can be educationally interesting, but GenoSight avoids supplement protocols, medication guidance, and symptom-cause claims.
Missing data stays visible
Consumer files do not cover every marker. Reports and checker pages keep compatibility, coverage, and clinical-confirmation caveats in view.
Privacy trade-off
Hosted reports, with clear data boundaries.
If you only want local, browser-only processing, GenoSight is not that. GenoSight is for people who want a saved account, PDF reports, citations, and follow-up chat while keeping the most sensitive boundary explicit: the raw genotype file does not go to the LLM.
Read the privacy walkthroughCompare browser-only vs hosted analysisNot browser-only, by design
GenoSight is a hosted report product. Your file uploads to your account so reports, PDFs, and findings chat can run across sessions.
Raw file stays out of the LLM
The analysis engines extract structured findings first. Anthropic receives those findings and your profile context, not the raw genotype file.
Encrypted storage, no data sales
Raw files are stored encrypted at rest, protected by account-scoped access controls, and are not sold to research partners or advertisers.
GenoSight vs Promethease, in practical terms
| Question | Promethease | GenoSight |
|---|---|---|
| Best fit | Exhaustive variant lookup | Readable, context-aware reports |
| Output style | Long SNP-level report | Prioritized summaries plus report sections |
| MTHFR and COMT context | Variant-by-variant lookup | Findings grouped into broader educational report context |
| Follow-up | Static report | Findings-grounded chat on paid plans |
| Clinical stance | Educational variant interpretation | Educational only, with clinician-confirmation caveats |
Pricing
Try the report first. Upgrade only if it helps.
Promethease is usually a one-time report purchase. GenoSight is credit-based: start free, then pick monthly, yearly, or lifetime access if you want more reports and findings chat.
Free trial
250 signup credits, no card
Enough to try one deeper report or two lighter reports before deciding whether the format is useful.
Start freeMonthly
1,500 credits per month
Good for active exploration after your first report: roughly one third of the current report library plus chat.
Choose monthlyYearly
18,000 credits per year
Best fit if you want the full library, regenerations, and follow-up chat across the year.
Choose yearlyLifetime
one-time
For people who expect to revisit reports over time and want ongoing access without renewals.
Choose lifetimeCommon questions
Is GenoSight a Promethease alternative?
Yes, if you already have a raw DNA file and want a readable educational report rather than an exhaustive SNP-by-SNP lookup. Promethease is still a better fit if you specifically want a large raw variant table.
Which raw DNA files does GenoSight accept?
GenoSight is built for consumer raw DNA files from 23andMe, AncestryDNA, and MyHeritage. It does not read PDF reports, screenshots, FASTQ, BAM, or whole-genome VCF files.
Does GenoSight explain MTHFR and COMT together?
GenoSight can put common MTHFR and COMT findings into broader educational report context instead of leaving them as isolated SNP rows. It still does not diagnose methylation problems, prescribe supplements, or claim that one variant explains symptoms by itself.
Does GenoSight process everything locally in my browser?
No. GenoSight is hosted so reports, PDFs, and findings chat can run under your account. If local-only processing is your main requirement, an in-browser open-source tool may be a better fit. GenoSight keeps the raw genotype file out of the LLM and does not sell genetic data.
Is GenoSight medical advice?
No. GenoSight provides educational genetic-health reports only. Consumer raw DNA data is not clinical confirmation, and medical decisions should be made with a qualified healthcare professional.
Try it with no card.
Upload your raw file, generate your first educational report, and decide whether the synthesis is useful before paying.