snps explained
GenoSight vs Promethease vs SelfDecode vs Nebula 2026
Compare raw DNA analysis services by workflow: Promethease for variant lookup, SelfDecode for a broad health platform, Sequencing.com for genome plans, and GenoSight for readable raw-file reports.
Sebastian Thorp · May 1, 2026 · 5 min read
In short
People usually compare raw DNA analysis services for one of four jobs: dense variant lookup, a broad health platform, whole-genome or genome-plan workflows, or a readable report from a file they already have. Promethease, SelfDecode, Sequencing.com, Nebula/DNA Complete context, and GenoSight each fit different parts of that map. This article is the narrative version; the shorter landing-page chooser is Raw DNA analysis comparison.
The contenders, briefly
Promethease. Promethease describes itself as a literature retrieval system that connects a DNA genotype file to scientific findings cited in SNPedia. It is the strongest fit when you want broad variant lookup and are willing to do your own triage.
SelfDecode. SelfDecode is a broader health platform with DNA reports, recommendations, lab tools, and AI features. Its own cost page says users with raw genetic data can upload a DNA file to get started for free, while full access, DNA analysis, and add-ons are paid.
Sequencing.com. Sequencing.com is a broader genome-plan and marketplace workflow. Its membership page says people with data from another DNA test can upload raw DNA data for free to get started, and it also offers whole-genome sequencing paths.
Nebula / DNA Complete. Nebula is best treated as legacy context. Nebula terms updated February 4, 2025 say active subscribers retain limited library and trait access, but Genome Analysis and Genome Browser are no longer available.
GenoSight. GenoSight reads compatible raw files from 23andMe, AncestryDNA, or MyHeritage and turns them into focused educational reports with source-linked caveats, PDFs, and findings-grounded chat on paid plans.
Functional comparison
| Feature | Promethease | SelfDecode | Sequencing.com | GenoSight |
|---|---|---|---|---|
| Reads existing 23andMe / AncestryDNA / MyHeritage file | Yes | Yes | Yes | Yes |
| Whole-genome sequencing offered | No | Kit/workflow dependent | Yes | No |
| Best fit | Exhaustive variant lookup | Broad health platform | Genome plans and marketplace | Focused report-first flow |
| AI or chat workflow | No findings chat | Yes, platform AI features | Platform dependent | Findings-grounded chat on paid plans |
| Output style | Dense SNPedia-linked report | Large report and recommendation library | Many report categories and apps | Focused readable reports |
| Clinical stance | Informational report | Educational health platform | Platform reports and plans | Educational only, not diagnosis |
| Good first action | Confirm you want a one-time lookup report | Confirm pricing and add-ons | Confirm plan breadth and data type | Run a no-card starter report |
Where each service is the right pick
Pick Promethease if you want exhaustive variant-level lookup, you are comfortable reading a dense report, and you mainly want a one-time literature-retrieval workflow. Promethease says most reports cost $25 and are produced in under 10 minutes. It also says generated reports and uploaded DNA data are deleted after delivery.
For the shorter landing-page version of that decision, see GenoSight as a Promethease alternative.
Pick SelfDecode if you want a broader health ecosystem, a large report library, lab tooling, and AI health features. It is not the same job as a small report-first raw-file tool. Before paying, check the current SelfDecode pricing page because membership, DNA analysis, kits, and add-ons are described separately.
For the shorter version, see GenoSight as a SelfDecode alternative.
Pick Sequencing.com if you want a genome-plan marketplace, long-term storage, many report categories, or a path toward whole-genome sequencing. It is broader than GenoSight by design, which can be a strength if you want that scope.
Do not treat old Nebula comparisons as current availability. Nebula/DNA Complete pages are still searched because many older reviews exist, but the current terms language says Genome Analysis and Genome Browser are no longer available.
Pick GenoSight if you already have a compatible 23andMe, AncestryDNA, or MyHeritage raw data file, want a readable first report, and value a follow-up chat that is grounded in generated findings rather than a giant SNP table.
Pricing and entry path
Competitor prices and bundles change, so confirm on the official site before paying. As checked on May 30, 2026:
| Service | Lowest public entry path | What to verify |
|---|---|---|
| Promethease | Most reports cost $25 | Whether you want a one-time SNPedia-linked lookup report |
| SelfDecode | Raw DNA upload to get started for free; paid platform and analysis paths | Membership, DNA analysis, kit, and add-on pricing |
| Sequencing.com | Upload raw DNA data for free to get started | Which genome plan or app/report you actually need |
| GenoSight | 250 free credits, no card | Whether a focused report-first workflow is enough |
GenoSight plans
| Plan | Price | What you get |
|---|---|---|
| Free trial | $0 | 250 signup credits, no card; enough for one deeper report or two lighter reports |
| Monthly | $11.99 / month | 1,500 credits per month for more reports, PDFs, regenerations, and findings chat |
| Yearly | $99.99 / year | 18,000 credits per year for broader library exploration over time |
| Lifetime | $229 once | Ongoing access with a recurring credit allowance and no subscription renewal |
Findings chat is 1 credit per message across paid plans.
How to actually decide
Ask three questions before uploading sensitive genetic data anywhere:
- Does it accept the file you already have? A 23andMe, AncestryDNA, or MyHeritage raw genotype file is different from a PDF report, screenshot, whole-genome VCF, FASTQ, or BAM.
- Will you read the output? A dense variant report is powerful if you can triage it. A focused report is better if you want synthesis first.
- Can you ask follow-up questions? A static report can be enough for lookup. Chat matters when you want report-grounded next questions.
Related: Raw DNA analysis comparison, the practical case for re-analyzing 23andMe with an independent tool, and the structural limits every consumer-array tool shares.
If GenoSight is the option you are evaluating now, compare the raw DNA health report path, the free DNA health report trial, the sample report, and pricing and free credits before you upload.
Compare services before uploading
See the shorter buyer-intent comparison, then start free or choose the monthly plan if GenoSight is the right workflow.
Ready to skip the comparison? Start GenoSight free or choose monthly.
Medical disclaimer
GenoSight provides educational information about genetic data. It is not a medical diagnosis, treatment, cure, clinical genetic test, or medication guide. Consumer raw DNA data can contain chip gaps, missing calls, and false positives. Medical decisions require qualified professional care and clinical confirmation.
Source notes
- Promethease home: https://promethease.com/
- Promethease privacy policy: https://promethease.com/privacy
- SelfDecode cost page: https://resources.selfdecode.com/blog/how-much-does-selfdecode-cost/
- Sequencing.com genome plans: https://sequencing.com/products/membership/
- Nebula customer terms update: https://nebula.org/blog/nebula-customer-user-terms-of-use/
Key takeaways
- Promethease is best understood as broad variant lookup.
- SelfDecode is best understood as a broader health platform.
- Sequencing.com is best understood as a genome-plan marketplace and sequencing path.
- Nebula/DNA Complete is mostly legacy comparison context because current Nebula terms say Genome Analysis and Genome Browser are no longer available.
- GenoSight is best when you want a readable educational report from an existing 23andMe, AncestryDNA, or MyHeritage raw DNA file, with no-card trial credits and an optional paid-plan chat workflow.
