23andMe COMT Val158Met marker
COMT rs4680 in 23andMe raw data.
If you are searching a 23andMe raw DNA file for COMT, the marker most people mean is rs4680, also called Val158Met. GenoSight can help you check whether that marker is present, then keep the interpretation cautious inside a broader educational report.
Start with marker coverage
Do this before interpreting the raw letters.
- Use the downloaded 23andMe raw genotype file, not a PDF or screenshot
- Search the file for rs4680, the common COMT Val158Met marker
- Treat a missing result as a coverage or no-call issue, not a clinical answer
- Interpret COMT with MTHFR, caffeine, stimulant response, stress, sleep, and clinician guidance
What to know before you search the file.
A raw-data search can answer a narrow coverage question. It cannot tell you, by itself, whether COMT explains your mood, stimulant response, methylation needs, or supplement tolerance.
23andMe raw data is a lookup tool
23andMe raw-data help explains that you can search by gene, marker, or genomic position, while keeping the data informational rather than diagnostic.
rs4680 is the usual COMT marker
rs4680 is commonly discussed as COMT Val158Met. It is one functional marker, not a complete dopamine, mood, methylation, or supplement answer.
GenoSight separates check from meaning
The free checker can show whether rs4680 appears in your file. A full report adds cautious context without turning one SNP into a protocol.
Keep raw data inside its limits.
GenoSight is educational only. It can help you move from a raw marker lookup to a structured report, but medical decisions require clinical confirmation, labs, current medications, and a qualified professional.
23andMe raw data navigation
Explains searching 23andMe raw data by gene, marker rsID, or genomic position and states the informational-use boundary.
23andMe raw genotype technical details
Explains strand reporting, reference genome language, and how uncalled variants can appear in downloaded raw data.
MedlinePlus COMT gene
Describes COMT and notes the Val108/158Met variation in a medical reference context without making consumer raw-data claims.
Next steps with a 23andMe file
Check rs4680 locally
Use the browser-only checker to see whether the marker appears in your file without uploading it.
Compare methylation context
COMT is often more useful when it is considered with MTHFR and adjacent methylation markers.
Run a full report
Create a no-card account and use your free credits to generate an educational report from a compatible file.
23andMe rs4680 and COMT questions
Can I find COMT rs4680 in 23andMe raw data?
Often, but not always. 23andMe chip versions, no-calls, and product changes can affect whether rs4680 appears in a specific raw genotype file.
Is rs4680 the same as COMT Val158Met?
Yes. rs4680 is commonly discussed as COMT Val158Met. Some references also mention Val108Met for a soluble COMT isoform, which is why naming can look inconsistent.
What if my 23andMe file does not show rs4680?
That usually means the marker is absent, uncalled, or represented differently in that file. It does not prove anything clinically by itself.
Can GenoSight analyze my 23andMe file for COMT?
Yes, if it is a compatible 23andMe raw genotype file. GenoSight can run an educational report that frames COMT with MTHFR, methylation context, caffeine and stimulant context, caveats, and source notes.