Raw DNA analysis comparison
Promethease vs SelfDecode vs Sequencing.com vs GenoSight.
If you already have a 23andMe, AncestryDNA, or MyHeritage raw DNA file, the right service depends on the job: dense variant lookup, a broad health platform, a genome-plan marketplace, or a focused educational report you can actually read.
How to choose safely
Match the workflow before uploading sensitive data.
- Check whether the service accepts your existing file.
- Decide whether you want lookup breadth or readable synthesis.
- Confirm pricing and privacy on the official site before paying.
- Do not use consumer raw DNA analysis as medical advice.
Service fit
Compare the workflow, not just the brand name.
Decision shortcut
Pick the smallest workflow that answers your question.
The cheapest first step is usually not the biggest platform. It is the workflow that turns your existing raw file into the kind of answer you will actually use.
Choose variant lookup
Pick this path when you want a very broad list of literature-linked variants and are comfortable reading a dense report yourself.
Promethease alternativeChoose a focused report
Pick this path when you want one readable report first, then decide whether PDFs, regenerations, and chat are worth paying for.
Pick a first reportChoose a broader platform
Pick this path when you want a health-platform or genome-marketplace account rather than a narrower raw-file report product.
Compare platformsGenoSight entry path
Start with a real report, then upgrade only if it earns it.
Free trial
250 credits, no card
$0
Enough to run the first report, including a 200-credit Detox and Methylation report.
Start freeMonthly
1,500 credits per month
$11.99
Good when the first report proves useful and you want more reports, PDFs, regenerations, and findings-grounded chat.
Choose monthlyYearly
18,000 credits per year
$99.99
Best for working through the broader report library over time after confirming the raw-file workflow fits.
Choose yearlyOfficial source notes
Competitor pricing and product availability can change. These links are the source trail used for this comparison on May 29, 2026; check each service before paying.
Promethease home
Describes Promethease as a literature retrieval system that connects DNA genotypes to SNPedia and notes most reports cost $25.
Promethease privacy policy
Describes the one-time report workflow, MyHeritage ownership, and deletion of generated reports and uploaded DNA data after delivery.
SelfDecode cost page
Describes free raw-DNA upload to get started, membership pricing, DNA upload/kit pricing, and optional add-on reports.
Sequencing.com membership page
Describes genome plan benefits and says people with data from another DNA test can upload raw DNA data for free to get started.
Nebula terms update
Updated February 4, 2025; says Genome Analysis and Genome Browser are no longer available for active subscribers.
Raw DNA analysis comparison questions
Which raw DNA analysis service should I use first?
Use the service that matches the job. Promethease fits dense variant lookup, SelfDecode fits a broad health platform, Sequencing.com fits a genome-plan marketplace, and GenoSight fits a readable report-first flow from an existing consumer raw DNA file.
Is GenoSight a replacement for Promethease or SelfDecode?
It can be an alternative for people who want focused educational reports, but it is not the same product. Promethease is broader variant lookup, and SelfDecode is a broader health platform.
Can I compare before paying?
Yes. GenoSight has a no-card free trial with 250 credits, a sample report, a raw-file checker, and a report picker so you can decide whether the format is useful before choosing a paid plan.
Is raw DNA analysis medical advice?
No. Consumer raw DNA analysis is educational. It should not be used as diagnosis, treatment advice, clinical confirmation, or medication guidance.
Compare first, upload second