AncestryDNA COMT Val158Met marker
COMT rs4680 in AncestryDNA raw data.
If you are searching an AncestryDNA raw DNA file for COMT, the marker most people mean is rs4680, also called Val158Met. GenoSight can help you check whether that marker is present, then keep the interpretation cautious inside a broader educational report.
Start with marker coverage
Do this before interpreting the raw letters.
- Use the AncestryDNA raw data download, usually a ZIP containing a text file
- Search the raw file for rs4680, the common COMT Val158Met marker
- Treat missing rs4680 as a coverage or no-call issue, not proof of anything clinical
- Interpret COMT with MTHFR, caffeine, stimulant response, stress, sleep, and clinician guidance
What to know before you search the file.
A raw-data search can answer a narrow coverage question. It cannot tell you, by itself, whether COMT explains your mood, stimulant response, methylation needs, or supplement tolerance.
AncestryDNA raw data is uninterpreted
Ancestry describes DNA Data as uninterpreted raw data generated from the AncestryDNA test, not as a clinical report or treatment guide.
Forward strand matters
Ancestry says its SNP data is reported on the forward strand with respect to the human reference genome, so strand language should stay explicit.
GenoSight keeps COMT cautious
The free checker can show whether rs4680 appears in your file. A full report adds context without using COMT as a personality label or supplement protocol.
Keep raw data inside its limits.
GenoSight is educational only. It can help you move from a raw marker lookup to a structured report, but medical decisions require clinical confirmation, labs, current medications, and a qualified professional.
Ancestry Support: downloading DNA data
Explains AncestryDNA raw data downloads, file contents, rsID columns, forward-strand reporting, and download troubleshooting.
Ancestry account-data download
Explains download email behavior and the reminder that downloaded copies are no longer protected by Ancestry account security.
MedlinePlus COMT gene
Describes COMT and notes the Val108/158Met variation in a medical reference context without making consumer raw-data claims.
Next steps with an AncestryDNA file
Check rs4680 locally
Use the browser-only checker to see whether the marker appears in your file without uploading it.
Compare methylation context
COMT is often more useful when it is considered with MTHFR and adjacent methylation markers.
Run a full report
Create a no-card account and use your free credits to generate an educational report from a compatible file.
AncestryDNA rs4680 and COMT questions
Can I find COMT rs4680 in AncestryDNA raw data?
Sometimes. AncestryDNA chip versions and no-call results can vary, so the practical first step is checking whether your own downloaded file contains rs4680.
Is rs4680 the same as COMT Val158Met?
Yes. rs4680 is commonly discussed as COMT Val158Met. Some sources also mention Val108Met for a soluble COMT isoform, which is why naming can look inconsistent.
What if my AncestryDNA file does not show rs4680?
That usually means the marker is absent, uncalled, or represented differently in that file. It does not prove anything clinically by itself.
Can GenoSight analyze my AncestryDNA file for COMT?
Yes, if it is a compatible AncestryDNA raw genotype file. GenoSight can run an educational report that frames COMT with MTHFR, methylation context, caffeine and stimulant context, caveats, and source notes.