Caffeine sensitivity DNA test
Check caffeine sensitivity from the raw DNA file you already have.
GenoSight can re-analyze a compatible 23andMe, AncestryDNA, or MyHeritage raw DNA file for supported caffeine-related markers, then frame ADORA2A sensitivity and CYP1A2 metabolism with your actual caffeine habits.
Useful for the caffeine-sensitive pattern
Jitters, anxiety, arousal, and sleep disruption need context.
- Works from compatible raw genotype files
- Looks for supported ADORA2A and CYP1A2 markers
- Adds caffeine amount and timing context
- Educational only, not a diagnosis or caffeine rule
What the report can and cannot answer
Caffeine sensitivity is not a single-gene verdict. GenoSight separates marker lookup from interpretation and keeps the output educational.
ADORA2A
Sensitivity, arousal, and anxiety context
ADORA2A rs5751876 is commonly discussed around caffeine-related arousal, jitters, anxiety, and sleep response. GenoSight treats it as context, not a diagnosis.
Read moreCYP1A2
Caffeine metabolism context
CYP1A2 rs762551 is commonly discussed around caffeine clearance. It is useful alongside dose, timing, sleep, medications, and habit context.
Read moreHabits
Your actual response matters
A caffeine sensitivity report is more useful when it knows whether you drink one morning coffee, energy drinks after lunch, or no caffeine at all.
Read moreKeep the result inside real-life context.
Your actual response can depend on dose, timing, sleep debt, baseline anxiety, medications, pregnancy status, tolerance, and blood pressure. Genetics should be one input, not the whole decision.
Provider starting points
Free first, monthly if useful
Ready to review caffeine sensitivity in context?
Caffeine sensitivity DNA test questions
Can a DNA test tell me if I am caffeine sensitive?
It can provide educational context from supported markers such as ADORA2A rs5751876 and CYP1A2 rs762551 when they are present in a compatible raw DNA file. It cannot diagnose anxiety, insomnia, or a personal caffeine limit.
Do I need a new caffeine sensitivity lab test?
Not for GenoSight. If you already have a compatible 23andMe, AncestryDNA, or MyHeritage raw genotype file, GenoSight can re-analyze supported caffeine-related markers from that file.
Can I check caffeine markers before uploading my file?
Yes. The caffeine raw data checker runs locally in your browser and shows whether selected markers appear in your file without uploading it.
Which GenoSight report should I run first?
The Foods & Drinks report is the direct starting point for caffeine sensitivity and metabolism questions. New accounts receive 250 free credits, and the report currently fits within that grant.