APOE raw DNA marker
APOE rs429358 in raw DNA data.
If you are searching a 23andMe, AncestryDNA, or MyHeritage raw genotype file for APOE, rs429358 is one of the two common markers people look for. GenoSight can check whether it is present without inferring APOE e-status on the free page.
Sensitive marker
Check only if you want APOE-related information.
- Browser-only local marker check
- Raw genotype string only
- No standalone APOE e-status inference
- Missing coverage is not a medical negative result
rs429358 is a lookup step, not the whole answer.
APOE is sensitive enough that GenoSight keeps marker presence, e-status interpretation, and medical decision-making in separate buckets.
What rs429358 is
rs429358 is one of the two common raw-data markers people look for when they are trying to understand APOE e2/e3/e4 context from a genotype file.
Why the pair matters
rs429358 should not be interpreted alone. APOE context commonly depends on rs429358 plus rs7412, file coverage, strand conventions, and careful caveats.
How GenoSight handles it
GenoSight can check marker coverage locally first, then handle APOE only inside sensitive educational report flows with clinical and insurance boundaries.
Evidence boundary
MedlinePlus describes APOE e4 as a risk factor for late-onset Alzheimer disease, not a diagnosis or certainty. GenoSight keeps rs429358 pages narrow and source-linked.
Provider starting points
If you are checking a specific raw DNA export, start with the matching provider page before interpreting APOE context.
23andMe rs429358
Search a 23andMe raw genotype file for rs429358 with sensitive-result caveats.
Open guideAncestryDNA rs429358
Check AncestryDNA raw data coverage before drawing APOE conclusions.
Open guideMyHeritage rs429358
Look for rs429358 in a MyHeritage raw DNA data file with paired-marker context.
Open guideAPOE rs429358 questions
Can I find APOE rs429358 in my 23andMe raw data?
Often, but coverage varies by provider, country, product, and chip version. Use the browser-only APOE raw data checker to see whether rs429358 is present in your specific file.
Is rs429358 the same as an APOE e4 result?
No. rs429358 is one marker used in APOE context, but it should not be turned into a standalone e2/e3/e4 label without rs7412 and source-aware interpretation.
Does missing rs429358 mean I have normal APOE risk?
No. Missing marker coverage is not a medical negative result. It usually means the raw file does not include that marker or that the file format was not readable.
Which GenoSight report should I start with?
For APOE questions, Heart Health, Aging & Longevity, and Foods & Drinks are the most relevant starting points. New accounts receive 250 free credits with no card required.